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KMID : 0390619950030010017
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Journal of Cardiovascular Ultrasound
1995 Volume.3 No. 1 p.17 ~ p.22
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A Clinical Study on the Antihypertensive Effect and the Changes of Left Ventricular Mass and Left Vetricular diastolic Function of Perindopril
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정욱성
박지원/윤호중/이만영/박준철/채장성/김재형/최규보/홍순조
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Abstract
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Background:
@EN Perindopril, a new second-generation angiotensin converting enzyme inhinbitor was administered in essential hypertensive patients in order to observe the clinical effects.
@ES Method:
@EN The change of blood pressure, heart rate, clinical laboratory examinations, side effects, electrocardiogram, echocardiographic left ventricular mass, and left ventricular diastolic function were evaluated before and after 4-8mg of perindopril
for 12
weeks administration in 20 essential hypertensive patients (male 4, female 16; mean age 57±12 years).
@ES Results:
@EN 1) The average of blood pressure of 20 subjects were systolic 172.5±17.4mmHg and diastolic 106.4±7.7mmHg before treatment which were lowered to 142.8±16.0mmHg and 88.6±8.6mmHg respectively ofter 12 weeks(P<0.05). There was no significant
reduction in heart rate.
2) The average of left ventricular mass before treatment was 287.5±61g, which was lowered to 251.3±39.7g. But there was no significant difference in left ventricular mass before and after treatment(P<0.05). The was no significant difference in
left
ventricular diastolic dysfunction before and after treatment.
3) Side effects were 2 cases of mild dry cough and 2 headache.
@ES Conclusion:
@EN Perindopril may be an effective initial single antihypertensive agent for the treatment of essential with little side effects.
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KEYWORD
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